Attrax® Technology

The Attrax ceramic surface has unique microstructure and microporosity that are optimized for bone formation. The unique microarchitecture of Attrax drives the differentiation of mesenchymal stem cells (MSCs) into bone-forming osteoblasts without added growth factors.1

AttraX Ceramics – Advanced Surface Technologies 1

Advanced biomaterial

Microarchitecture drives bone formation

Traditional calcium phosphate materials generally do not give rise to bone formation when implanted in an intramuscular pouch, unless osteoinductive or osteogenic factors are added. Due to its optimized microarchitecture, Attrax® has a unique ability to consistently form bone in intramuscular defects without adding osteogenic cells or proteins.3

Optimized microarchitecture

Deliberately engineered. Intelligently designed.

The Attrax ceramic surface has unique microstructure and microporosity that are optimized for bone formation. The unique microarchitecture of Attrax drives the
differentiation of mesenchymal stem cells (MSCs) into bone-forming osteoblasts without added growth factors.1

The optimized microarchitecture of Attrax is engineered using tightly controlled parameters for a defined micropore size distribution within 0.3 to 1.1 microns. Traditional calcium phosphate materials falling outside of this specification do not possess the unique ability of Attrax to form bone consistently inintramuscular defects.

AttraX Ceramics – Advanced Surface Technologies 2

Fusion performance

Fusion equivalent to Autograft

In a large animal instrumented  posterolateral fusion (PLF) model, Attrax fusion rates were equivalent to or better than autograft, and faster than traditional synthetic.5-7*

*Data from intramuscular and spine preclinical models may not be representative of clinical outcomes.

Fusion superior to traditional synthetic ceramic grafts

Spinal segments fused with Attrax had greater biomechanical strength than segments treated with ACTIFUSE ABX or Vitoss BA in a rabbit PLF model.8

Statistically lower than Attrax Putty (P<0.05).

Learn more about Attrax

1. Yuan H, Fernandes H, Habibovic P, et al. Osteoinductive ceramics as a synthetic alternative to autologous bone grafting. PNAS 2010;107(31):13614-9. 2. Yuan H, Luo X, Barbieri D, et al. Superiority of nanostructured calcium phosphate bone graft substitutes for bone regeneration. 9th World Biomaterials Congress 2012. Chengdu, China. 3. Barbieri D, Yuan H, Ismailoglu AS, et al. Comparison of two moldable calcium phosphate-based bone graft materials in a noninstrumented canine interspinous implantation model. Tissue Eng Part A 2017;23(23- 24):1310-20. 4. Duan R, Barbieri D, Luo X, et al. Variation of the bone forming ability with the physicochemical properties of calcium phosphate bone substitutes. Biomater Sci 2018;6:136-45. 5. Vizesi F, Cunningham B, Hu N, et al. Nanostructured TCP in the sheep posterolateral fusion model. 9th World Biomaterials Congress 2012. Chengdu, China. 6. Ismailoglu AS, Vizesi F, Cunningham B, et al. Fibrillar collagen/ TCP scaffold in the sheep posterolateral fusion model. Society for Biomaterials Annual Meeting 2012. New Orleans, LA, USA. 7. Fredericks DC, Smucker JD, Peterson EB, et al. Novel TCP compares favorably to autograft in posterolateral fusion: evaluation in rabbit and sheep models. International Society for the Advancement of Spine Surgery 2013 Annual Conference. Vancouver, BC, Canada. 8. Walsh WR, Degroot F, Bertollo N, et al. Nanostructured TCP in rabbit posterolateral fusion compared to commercial osteobiologics. American Academy of Orthopaedic Surgeons 2011 Annual Meeting. San Diego, CA, USA.