Allograft – Tissue taken from one individual (the donor) and implanted in another individual of the same species (the recipient). Allograft tissue is regulated by the AATB and by the FDA under allograft-specific regulations in the United States.
Autograft – Tissue graft from the patient’s own body. Examples of bone autograft in spine surgery include iliac crest and local bone from the surgical site. May also be referred to as autogenous bone.
Differentiation (of cells) – The process by which a less specialized cell, which has the potential to become many cell types, becomes a more specialized cell, with very specific functions.
Immune response – This is is how your body recognizes and defends against substances that appear foreign and harmful. Standard laboratory tests confirm that Osteocel does not cause an immune response. Osteocel was shown not to provoke an immune response in a standard laboratory test.
Immunodepletion – The process used to remove all of the components in Osteocel that have the potential to provoke an immune response.
Mesenchymal Stem Cells (MSCs) – Cells that have the ability to differentiate into bone, cartilage, and fat. When signaled to form bone, MSCs differentiate into osteoprogenitor cells and then osteoblasts, the bone-forming cells.
Osteoblasts – Cells that build bone. MSCs can differentiate into osteoblasts.
Osteoconductive – Used to describe a graft material’s ability to provide scaffolding for bone to grow onto.
Osteoinductive – Used to describe materials or signals that have the potential to induce bone formation.
Osteoprogenitor cells – Cells that are in between MSCc and osteoblasts in the cell differentiation process. Osteocel retains MSCs and osteoprogenitor cells.
Scaffold – A supporting structure that reinforces new bone formation through cell and protein attachment. In Osteocel, the cancellous bone matrix acts as a scaffold.